Introduction: The Mpox epidemic in non-endemic regions is now attracting global attention. The DRC alone reports nearly 85% of known human cases. In the Tshopo province, the Isangi Territory has experienced outbreaks of this disease in recent years. The objective of this study was to assess the link between the disease and various associated factors.
Methods: An analytical cross-sectional study was conducted in three health zones of the Isangi territory (Yakusu, Yahisuli, and Yabaondo health zone) from January 2023 to January 2024. It included 460 subjects, and data was collected using investigation forms and guided interviews with a survey questionnaire. A bivariate analysis was conducted to determine the factors associated with Mpox infection. With a significance level of 5%, odds ratios were calculated with their corresponding confidence intervals. Results: Factors associated with Mpox infection were hunting, fishing, agriculture, Wildlife Trade, poverty, contact with an infected animal, interaction with a sick person, and sharing a bed with a sick person. Conclusion: Mpox epidemics are recurrent in Isangi due to various identified factors. Community sensitization, case investigation, and notification are essential for the prevention and control of this disease in Isangi.