Mpox is a viral zoonosis caused by the Mpox virus. The rise in cases in endemic regions since 2005 is strongly correlated with environmental changes such as climate change, deforestation, and human migration.
Isangi Territory has experienced repeated Mpox over the past three years. This situation coincides with recurrent floods and significant anthropogenic pressure on the environment, leading to substantial changes in land use.
Methods: This descriptive study aimed to describe the ecological profile of health areas affected by the Mpox epidemic in Isangi Territory, using remote sensing data and field surveys. We analyzed land-use changes between 2010 and 2024 using Landsat 5 (2010) and Landsat 8 (2024) satellite imagery, mapping the forest cover of the Yabaondo, Yakusu, and Yahisuli reserves.
Results: Health areas reporting suspected cases were characterized by deforested primary forests, oil palm plantations, experienced seasonal flooding and Areas with fallow land and secondary forest reported 
Our results reveal a possible link between Mpox and the Isangi landscape.
Conclusion: Cases predominantly occur in oil palm plantations and deforested areas, suggesting that ecosystem modifications favor transmission. Flood-prone areas also play a role, confirming the importance of landscape ecology for public health strategies.