Title:
PROBING RESEARCH PRECINCTS FOCUSED ON SYSTEMATIC DETERMINATION OF THE BIOLOGICAL EFFECTS OF MACROMOLECULAR INTERACTIONS

Authors:
Dr Chrysanthus Chukwuma Sr

Abstract:
The morphological arrangement of interacting chemical groups in a binding or an active site presents an increased magnitude of interaction specificity and affinity which are crucial to biological functionality. The configuration and functionality of macromolecules are influenced via the dynamics of covalent bonds and polarity, bond rotations and vibrations, non-covalent interactions, hydrophobic impact and molecular structure. Macromolecular interactions comprise diverse non-covalent interactions with specificity and precision which are crucial to biological functions. Molecular interactions are the crux of all cellular processes, viz: catalysis, recognition and signal transduction, whereby several diseases or disorders can be directly associated with aberrant interactions between molecular pairs which provide the latitude for drug design capable of reversing aberrant biophysical features. Sedimentation rate, as a physical method and sophisticated technique is used to investigate macromolecular interactions that necessitates optimum precision in both experimental design and data analysis. The kinetic analysis of an expansive array of macromolecular interactions with evolving of experimental design and data analysis provide for accurately defined assembly of mechanisms and rate constants correlated with macromolecular interactions.

Keywords:
bonding, cellular processes, human diseases, experimental designs, targets, spatiotemporal variations, drugs