This study examined the association between socio-demographic characteristics and posttraumatic stress disorder (PTSD) symptom severity among intensive care unit (ICU) healthcare professionals in the conflict-affected, resource-constrained context of Bui Division, Cameroon. In a cross-sectional study of 134 ICU professionals (nurses, physicians, and support staff), PTSD symptoms were assessed using the PTSD Checklist for DSM-5 (PCL-5). The prevalence of probable PTSD was exceptionally high (94.8%), with a mean PCL-5 score of 42.22 (SD = 5.55) significantly above the clinical threshold. Inferential analysis using a General Linear Model found no statistically significant associations between PTSD symptom severity and any of the examined socio-demographic variables, including age, gender, marital status, professional role, length of ICU experience, and working hours (all p > .05, partial η² ≤ .014). The findings indicate uniformly severe PTSD symptoms across the ICU workforce, suggesting that in high-stress, fragile contexts, pervasive occupational and environmental stressors may overwhelm individual socio-demographic risk or protective factors. This underscores the necessity for system-wide mental health interventions and support structures targeting all ICU personnel in such settings, rather than selectively focused strategies.